Endocrine Abstracts

Glypican-4 (Gpc-4) is novel adipokine interact with insulin receptor and affects insulin sensitivity in proteoglycans. Gpc-4 serum levels show gender differences; females having higher levels than men, what can suggest mediation by sex hormones. We investigated serum Gpc-4 levels and its association with cardiovascular risk predictors in women (20–35 years old) with PCOS (n=62) and healthy control (n=43) presented different sex hormones profile. The foll...

The endocannabinoid system has been suspected to contribute to the association of visceral fat accumulation with metabolic diseases. Insulin resistance play important role in etiology in PCOS. The aim of our study was developed the role of CNR1 polymorphisms (rs806368, rs12720071, rs1049353, 806381, rs10485170, rs6454674, rs2023239) in metabolic disorders in woman with PCOS. 88 woman (20–35 years old) with PCOS (recognized using Rotterdam criteria) and 77 woman (20–3...